It seems that the players I know are either playing in the career mode, or MyTeam (gathering players into a fantasy league of sorts) or street basketball on the internet, so these three modes are the main focus for this analysis.
In the past street basketball is slightly different in comparison to indoor basketball. Partly because you play 3-on-3 and have more space in the court, and partly because the opponents on the street are controlled by players and not by computers. However, it is also because 2K prefers to give street basketball more of an arcade feel.
The game's matchmaking is excellent and in general you compete against teams that are relatively evenly and well-matched. Your player score isn't the most important thing, but more about how smart (or dumb) you're playing. It's cringe-inducing when you're paired together with a player who doesn't defend and simply want to shoot 3-pointers, however, it's impossible to avoid that.
Street basketball is slightly better than the previous year and, most importantly, you feel like you've got a little more control over the actions of your player. In the past, you would be stuck within an animation that required to be played before you could move on to the next. This is not the case in 2K22.
There are a variety of new game modes have been added to MyTeam. For instance, online, you can play the game MyTeam Draft, where you must first choose the number of players are not on your list. That makes the game a considerably more exciting than the previous versions.
"The 100" is an excellent addition. It is not recommended to score more than 100 total points against multiple opponents. The player who is the last (and has defended the best) takes home the victory. MyTeam continues to do everything it can to convince players to purchase player packs or player contracts after purchasing the game. There isn't any improvement to be seen.